Longevity and testosterone

Calorie Restriction, Longevity and Cognitive Function

Exogenous Testosterone, Finasteride and Castration Effects on Testosterone, Insulin, Zinc and Chromium in Adult Male Rats

Background: Although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. The aim of the present study was to evaluate the effect of testosterone and finasteride administration and castration on serum levels of testosterone, insulin, zinc and chromium. Methods: Male adu...

calorie restriction, longevity and cognitive function

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Homocysteine and Familial Longevity: The Leiden Longevity Study

Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevity by testing whether homocysteine is lower in individuals that are genetically enriched for longe...

Loneliness, health, and longevity.

BACKGROUND Objective measures of loneliness and poor social contacts are associated with negative health outcomes. However, the influence of subjective loneliness among elderly persons is poorly documented. We hypothesized that loneliness among persons aged 70-90 years is associated with subsequent decline in health, function, and longevity. METHODS Mortality data for subjects aged 70-90 year...